文献类型：会议论文

英文题名：Folate conjugated CdHgTe quantum dots with high targeting affinity and sensitivity for in vivo early tumor diagnosis

作者：Chen, Haiyan[1]; Li, Li[2]; Cui, Sisi[1]; Mahounga, Dider[1]; Zhang, Jun[1]; Gu, Yueqing[3]

第一作者：Chen, Haiyan

通讯作者：Gu, Y.

机构：[1] Department of Biomedical Engineering, School of Life Science and Technology, China Pharmaceutical University, 24 Tongjia Lane, Gulou District, Nanjing 210009, China; [2] XinXiang College of Chemistry and Chemical Engineering, Xinxiang University, XinXiang City 453003, Henan Province, China; [3] China Pharmaceutical University, Nanjing, China

第一机构：Department of Biomedical Engineering, School of Life Science and Technology, China Pharmaceutical University, 24 Tongjia Lane, Gulou District, Nanjing 210009, China

通讯机构：[3]China Pharmaceutical University, Nanjing, China

语种：英文

外文关键词：Cadmium alloys - Diagnosis - Diseases - Fluorescence imaging - Infrared devices - Semiconductor alloys - Semiconductor quantum dots - Thermography (imaging) - Tumors

摘要：CdHgTe-folate conjugates, acting as novel active-targeting fluorescence probes, were prepared by covalent conjugation of CdHgTe QDs and folic acid. Their characteristics, such as optical spectra, stability and cancer cell targeting were investigated in detail. The fluorescence wavelength of CdHgTe-folate conjugates was 790 nm and a full width at half-maximum (FWHM) of them was 50-70 nm. Their fluorescence stability could satisfy the need of long and continuous fluorescence imaging. The in vivo dynamic bio-distribution of CdHgTe-folate conjugates in S180 tumor beard mouse model was monitored by a NIR imaging system. The resultes indicated that CdHgTe-folate conjugates targeted to tumor effectively. The high fluorescence intensity together with targeting effect makes CdHgTe-folate conjugates promising candidates for imaging, monitoring and early diagnosis of cancer at molecular and cell level. ? 2010 Springer Science+Business Media, LLC.