文献类型：期刊文献

英文题名：Novel electrochemical strategy for determination of anticancer drug flutamide based on MXene/MOF composite

作者：Li, Yawen[1];Zhang, Le[1];Wu, Mingyuan[1];Ma, Guoyang[1];Motlak, Mahmoud[2];Mahdi, Ahmed[1,2]

第一作者：Li, Yawen

通讯作者：Li, YW[1];Motlak, M[2]

机构：[1]Xinxiang Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China;[2]Univ Mosul, Dept Chem, Mosul, Iraq

第一机构：新乡学院

通讯机构：[1]corresponding author), Xinxiang Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China;[2]corresponding author), Univ Mosul, Dept Chem, Mosul, Iraq.|[11071]新乡学院;

年份：2023

卷号：155

外文期刊名：INORGANIC CHEMISTRY COMMUNICATIONS

收录：;Scopus(收录号：2-s2.0-85165273943);WOS:【SCI-EXPANDED(收录号:WOS:001043301100001)】；

基金：This work was supported by the Henan Provincial Key R & D and promotion project program (Grant Nos. 232102231034) , and also sup- ported by the Henan Provincial Key scientific research project program of Higher Education Institutions (Grant Nos. 23A150051) .

语种：英文

外文关键词：Flutamide; Electrochemical sensor; MXene; Composite; Metal-organic framework

摘要：In the present study, MXene/metal-organic framework (MOF(ZIF-67)) nanocomposite was prepared using coprecipitation process at room temperature and its performance for flutamide detection in biological samples was investigated. The sensing ability of the modified electrode was explored with electrochemical impedance spectroscopy and cyclic voltammetry techniques. With respect to the electrocatalytic ability of ZIF-67 and excellent electrical conductivity of MXene nanosheets, the suggested sensor illustrated significant sensitivity in the measuring of the anti-cancer drug. The established electrochemical system displayed a low detection limit of 0.015 & mu;M using differential pulse voltammetry procedure at the optimum conditions. Besides, the derived electrode showed diverse advantages including good selectivity, acceptable reproducibility, high stability, wide calibration range (0.05-70 & mu;M), short analysis time and convenience for flutamide analysis. Interestingly, the efficiency of the proposed platform remains unchanged in analysis of flutamide in body fluids with complex matrices.