文献类型：期刊文献

英文题名：Synthesis of cycloalkyl substituted purine nucleosides via a metal-free radical route

作者：Wang, Dong-Chao[1,2];Xia, Ran[1,3];Xie, Ming-Sheng[2];Qu, Gui-Rong[2];Guo, Hai-Ming[1,2]

第一作者：Wang, Dong-Chao

通讯作者：Guo, HM[1];Qu, GR[2];Guo, HM[2]

机构：[1]Henan Normal Univ, Sch Environm, Xinxiang 453007, Henan Province, Peoples R China;[2]Henan Normal Univ, Sch Chem & Chem Engn, Key Lab Green Chem Media & React, Minist Educ, 46 Jianshe Rd, Xinxiang 453007, Peoples R China;[3]Xinxiang Univ, Sch Chem & Chem Engn, Xinxiang 453003, Peoples R China

第一机构：Henan Normal Univ, Sch Environm, Xinxiang 453007, Henan Province, Peoples R China

通讯机构：[1]corresponding author), Henan Normal Univ, Sch Environm, Xinxiang 453007, Henan Province, Peoples R China;[2]corresponding author), Henan Normal Univ, Sch Chem & Chem Engn, Key Lab Green Chem Media & React, Minist Educ, 46 Jianshe Rd, Xinxiang 453007, Peoples R China.

年份：2016

卷号：14

期号：18

起止页码：4189-4193

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20162002403832);Scopus(收录号：2-s2.0-84967152761);WOS:【SCI-EXPANDED(收录号:WOS:000375610600003)，CCR-EXPANDED(收录号:WOS:000375610600003)】；

基金：We are grateful for financial support from the National Natural Science Foundation of China (no. 21372066 and 21472037), the National Basic Research Program of China (973 Program, no. 2014CB560713), the Plan for Scientific Innovation Talent of Henan Province (164200510008), and Henan Normal University National Outstanding Youth Cultivation Fund (14JR003).

语种：英文

外文关键词：Activation analysis - Aromatic compounds - Free radicals - Reaction kinetics

摘要：An efficient route to synthesize cycloalkyl substituted purine nucleosides was developed. This metal-free C-H activation was accomplished by a tBuOOtBu initiated radical reaction. By adjusting the amount of tBuOOtBu and reaction time, the selective synthesis of C6-monocycloalkyl or C6,C8-dicycloalkyl substituted purine nucleosides could be realized. Furthermore, uracil and related nucleosides were also suitable substrates, giving the C5-cyclohexyl substituted uracil derivatives in good yields with excellent regioselectivities.