文献类型：期刊文献

中文题名：肝素化/类肝素化高分子膜材料的研究进展

英文题名：Research progress of heparinized/heparin-like polymer membrane materials

作者：杨倩[1];谢艳新[1];沈宇杰[2];朱宝库[1,2]

机构：[1]新乡学院化学化工学院,河南新乡453003;[2]浙江大学高分子科学与工程学系,杭州310027

第一机构：新乡学院化学化工学院

年份：2019

卷号：50

期号：12

起止页码：12059-12065

中文期刊名：功能材料

外文期刊名：Journal of Functional Materials

收录：CSTPCD;;Scopus;北大核心:【北大核心2017】；CSCD:【CSCD2019_2020】；

基金：国家重点研发计划资助项目(2017YFE0114100);河南省高等学校重点科研资助项目(17A530010);新乡学院科技创新团队资助项目(XXUTD20170111)

语种：中文

中文关键词：高分子膜材料;肝素化;类肝素化;抗凝血性能

外文关键词：polymer membrane material;heparin immobilization;heparin-like;anticoagulation

摘要：一般的高分子材料与血液接触时,在材料表面会形成血栓,无法满足抗凝血的要求。将肝素或类肝素物质通过适当的方法固定在高分子材料上,可以提高材料的抗凝血性能。对改善高分子材料血液相容性的方法进行了总结,叙述了肝素化/类肝素化高分子膜材料的特征与优势,重点介绍了肝素化/类肝素化抗凝血高分子膜材料的制备方法研究进展,并对类肝素化高分子膜材料的发展方向进行了展望。
When polymer materials contact with blood, thrombus is formed on the surface of the material, and the requirements of anticoagulation cannot be met. Heparin or heparin-like substances can be immobilized on the polymer materials by appropriate methods to improve the antithrombogenicity of the materials. In this paper, the methods for improving the blood compatibility of polymer materials were summarized, and the characteristics and strengths of heparinized/heparin-like polymer membrane materials were described. The paper focused on the introduction of the research progress of the heparinized/heparin-like anticoagulant polymer membrane materials on its preparation and production methods, and the further research direction of heparin-like polymer membrane materials was prospected.