文献类型：期刊文献

英文题名：Toward improved human health: efficacy of dietary selenium on immunity at the cellular level

作者：Xia, Xiaojing[1];Zhang, Xiulin[2];Liu, Mingcheng[1];Duan, Mingyuan[1];Zhang, Shanshan[1];Wei, Xiaobing[1];Liu, Xingyou[3]

第一作者：Xia, Xiaojing

通讯作者：Wei, XB[1];Liu, XY[2]

机构：[1]Henan Inst Sci & Technol, Coll Anim Sci & Vet Med, Xinxiang 453003, Henan, Peoples R China;[2]Shanxi Agr Univ, Coll Vet Med, Jinzhong 030801, Shanxi, Peoples R China;[3]Xinxiang Univ, Xinxiang 453003, Henan, Peoples R China

第一机构：Henan Inst Sci & Technol, Coll Anim Sci & Vet Med, Xinxiang 453003, Henan, Peoples R China

通讯机构：[1]corresponding author), Henan Inst Sci & Technol, Coll Anim Sci & Vet Med, Xinxiang 453003, Henan, Peoples R China;[2]corresponding author), Xinxiang Univ, Xinxiang 453003, Henan, Peoples R China.|[11071]新乡学院;

年份：2021

卷号：12

期号：3

起止页码：976-989

外文期刊名：FOOD & FUNCTION

收录：;EI(收录号：20210809961249);Scopus(收录号：2-s2.0-85100938723);WOS:【SCI-EXPANDED(收录号:WOS:000618057700004)】；

基金：The study described in this article was funded by the Key Specialized Research and Development Break-through Program in Henan Province (No. 202102110101), the Modern Agriculture Industry Technical System of Henan Province, China (S2012-06-G02), the National Natural Science Foundation of China (No. 31702263 and 31972715), the Youth Backbone Teacher Project of Colleges and Universities of Henan Province (No. 2020GGJS163) and the Young Talent Lifting Project in Henan Province (2021HYTP038).

语种：英文

外文关键词：Signal transduction - Trace elements

摘要：Selenium, an essential trace element in the body, participates in various biological processes in the form of selenoproteins. In humans, a suitable concentration of selenium is essential for maintaining normal cellular function. Decreased levels of selenoproteins can lead to obstruction of the normal physiological functions of tissues and cells and even death. In addition, the level of selenium in the body affects cellular immunity, humoral immunity, and the balance between type 2 and type 1 helper T cells. Selenium can affect the immune function of the body through the reactive oxygen species (ROS), NF-kappa B, ferroptosis and NRF2 pathways. This paper reviews the immune effect of selenium on the body and the process of signal transduction and aims to serve as a reference for follow-up studies of immune function and research on the development of new selenium compounds and active targets.