文献类型：期刊文献

中文题名：鸡传染性法氏囊病病毒VP2蛋白及其疫苗的研究进展

英文题名：Research Progress on VP2 Protein and Vaccine of Infectious Bursal Disease Virus

作者：韩玉婷[1];何勇[2];许革学[3];朱艳平[2];马秀园[1];王选年[1,2]

第一作者：韩玉婷

机构：[1]河南科技学院动物科学学院;[2]新乡学院生物技术研究中心/生命科学与技术系;[3]灵宝市畜牧局

第一机构：河南科技学院动物科学学院,河南新乡453003

年份：2016

卷号：45

期号：3

起止页码：20-23

中文期刊名：河南农业科学

外文期刊名：Journal of Henan Agricultural Sciences

收录：CSTPCD;;北大核心:【北大核心2014】；CSCD:【CSCD_E2015_2016】；

基金：新乡市科技创新平台项目(CP1311)

语种：中文

中文关键词：鸡;传染性法氏囊病病毒;VP2蛋白;疫苗

外文关键词：chicken; IBDV; VP2 protein; vaccine;

摘要：传染性法氏囊病病毒(IBDV)是鸡传染性法氏囊病(IBD)的病原。近年来IBDV变异毒株和超强毒株的流行,严重威胁着世界养鸡业的发展,传统疫苗已不能控制IBDV的流行,迫切需要研制新型疫苗。IBDV VP2蛋白是重要的结构蛋白,能诱导机体产生中和抗体,因此,利用VP2蛋白制备IBDV重组疫苗成为国内外研究的热点。综述了IBDV VP2蛋白的作用及在不同表达系统中用VP2蛋白制备疫苗的研究进展,以期为IBDV新型疫苗的开发提供参考。
Infectious bursal disease virus（ IBDV） is a pathogen causing chicken infectious bursa disease（ IBD）. Due to the variation of IBDV strains and the prevalence of super virus in recent years,IBD become a serious disease that may threat to the development of the world chicken industry. The traditional vaccine is unable to resist the prevalence of IBD,and new IBD vaccine is urgently needed to control the spread of IBDV. As an important structural protein of IBDV,VP2 protein is used to prepare recombinant vaccine. It is an investigative hot spot for home and abroad experts. In this overview,the IBDV VP2 protein function and the research progress of using VP2 protein to prepare vaccine in different expression system were summarized,so as to provide reference for the development of new IBDV vaccines.