文献类型：期刊文献

英文题名：Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development

作者：Sun, Weiwei[1];Dai, Lili[1];Cao, Yuqing[1];Pan, Pengtao[1];Zhi, Lijuan[1];Wang, Xinke[1];Yuan, Xinzhong[1];Gao, Zi[1];Guo, Sheng[2];Liu, Guoyan[1];Yin, Junlei[1];Xie, Liangliang[1];Wang, Liping[1];Wang, Yanling[1];Li, Wensheng[1];Li, Hong[1];Jia, Yunjie[1]

第一作者：Sun, Weiwei

通讯作者：Sun, WW[1]

机构：[1]Xinxiang Univ, Sch Med, Jinsui Rd 191, Xinxiang 453003, Peoples R China;[2]Xinxiang Med Univ, Sch Basic Med Sci, Dept Immunol, Xinxiang, Peoples R China

第一机构：新乡学院

通讯机构：[1]corresponding author), Xinxiang Univ, Sch Med, Jinsui Rd 191, Xinxiang 453003, Peoples R China.|[11071]新乡学院;

年份：2023

卷号：14

期号：1

外文期刊名：CANCER NANOTECHNOLOGY

收录：;Scopus(收录号：2-s2.0-85153305137);WOS:【SCI-EXPANDED(收录号:WOS:000972810400003)】；

语种：英文

外文关键词：Tumor microparticles; Monocytes; Monocyte-derived DCs; IRF4; Tumor vaccine

摘要：Tumor microparticles (T-MPs) are considered as a tumor vaccine candidate. Although some studies have analyzed the mechanism of T-MPs as tumor vaccine, we still lack understanding of how T-MPs stimulate a strong anti-tumor immune response. Here, we show that T-MPs induce macrophages to release a key chemotactic factor CCL2, which attracts monocytes to the vaccine injection site and enhances endocytosis of antigen. Monocytes subsequently enter the draining lymph node, and differentiate into monocyte-derived DCs (moDCs), which present tumor antigens to T lymphocytes and deliver a potent anti-tumor immune response. Mechanically, T-MPs activate the cGAS-STING signaling through DNA fragments, and then induce monocytes to upregulate the expression of IRF4, which is a key factor for monocyte differentiation into moDCs. More importantly, monocytes that have endocytosed T-MPs acquire the ability to treat tumors. Collectively, this work might provide novel vaccination strategy for the development of tumor vaccines and facilitate the application of T-MPs for clinic oncotherapy.