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The Convenient Synthesis of Unsaturated Nucleoside Analogues in Water under Microwave Irradiation  ( SCI-EXPANDED收录)  

文献类型:期刊文献

英文题名:The Convenient Synthesis of Unsaturated Nucleoside Analogues in Water under Microwave Irradiation

作者:Xia, Ran[1];Sun, Li-Ping[2]

第一作者:Xia, Ran

通讯作者:Xia, R[1]

机构:[1]Coll Chem & Chem Engn, Xinxiang City, Henan Province, Peoples R China;[2]Xinxiang Univ, Sch Life Sci & Technol, Xinxiang City, Henan Province, Peoples R China

第一机构:Coll Chem & Chem Engn, Xinxiang City, Henan Province, Peoples R China

通讯机构:[1]corresponding author), Xinxiang Univ, Coll Chem & Chem Engn, Xinxiang, Peoples R China.|[110713]新乡学院化学化工学院;[11071]新乡学院;

年份:2016

卷号:35

期号:2

起止页码:76-82

外文期刊名:NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

收录:;Scopus(收录号:2-s2.0-84958874144);WOS:【SCI-EXPANDED(收录号:WOS:000370667500003),CCR-EXPANDED(收录号:WOS:000370667500003)】;

语种:英文

外文关键词:green solvent; unsaturated nucleoside; convenient synthesis; Microwave irradiation

摘要:A convenient method for the regioselective synthesis of unsaturated nucleoside analogs in water under microwave irradiation was developed. All pyrimidine and purine nucleoside derivatives were exclusively alkylated at N1 and N9 respectively in good to excellent yields. In addition, this system could tolerate a broad range of functional groups, such as chloro, bromo, iodo, alkyl, amino, and hydroxyl groups. More importantly, the reaction scale could be enlarged to 50 mmol which made this route attractive for industrial application.

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