文献类型：期刊文献

英文题名：Folate Conjugated CdHgTe Quantum Dots with High Targeting Affinity and Sensitivity for In vivo Early Tumor Diagnosis

作者：Chen, Haiyan[1];Li, Li[2];Cui, Sisi[1];Mahounga, Dider[1];Zhang, Jun[1];Gu, Yueqing[1]

第一作者：Chen, Haiyan

通讯作者：Gu, YQ[1]

机构：[1]China Pharmaceut Univ, Dept Biomed Engn, Sch Life Sci & Technol, Nanjing 210009, Peoples R China;[2]Xinxiang Univ, XinXiang Coll Chem & Chem Engn, XinXiang City 453003, Henan Province, Peoples R China

第一机构：China Pharmaceut Univ, Dept Biomed Engn, Sch Life Sci & Technol, Nanjing 210009, Peoples R China

通讯机构：[1]corresponding author), China Pharmaceut Univ, Dept Biomed Engn, Sch Life Sci & Technol, 24 Tongjia Lane, Nanjing 210009, Peoples R China.

年份：2011

卷号：21

期号：2

起止页码：793-801

外文期刊名：JOURNAL OF FLUORESCENCE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000291061500036)】；

基金：The authors are grateful to Natural Science Foundation Committee of China (NSFC81000666, NSFC81071194, NSFC30970776, NSFC30700779), the Ministry of Science and Technology (2009ZX09310-004), the Ministry of Education of China and China Pharmaceutical University for their financial supports.

语种：英文

外文关键词：CdHgTe; Folate; Near infrared imaging; Cancer; Targeting

摘要：CdHgTe-folate conjugates, acting as novel active-targeting fluorescence probes, were prepared by covalent conjugation of CdHgTe QDs and folic acid. Their characteristics, such as optical spectra, stability and cancer cell targeting were investigated in detail. The fluorescence wavelength of CdHgTe-folate conjugates was 790 nm and a full width at half-maximum (FWHM) of them was 50-70 nm. Their fluorescence stability could satisfy the need of long and continuous fluorescence imaging. The in vivo dynamic bio-distribution of CdHgTe-folate conjugates in S180 tumor beard mouse model was monitored by a NIR imaging system. The resultes indicated that CdHgTe-folate conjugates targeted to tumor effectively. The high fluorescence intensity together with targeting effect makes CdHgTe-folate conjugates promising candidates for imaging, monitoring and early diagnosis of cancer at molecular and cell level.