文献类型：期刊文献

英文题名：Highly Efficient and Diastereoselective Construction of Tricyclic Pyrrolidine-Fused Benzo[b]thiophene 1,1-dioxide Derivatives via 1,3-Dipolar [3+2] Cycloaddition

作者：Wang, Kai-Kai[1];Li, Yan-Li[2];Ma, Guo-Yang[1];Yi, Meng-Hao[1];Zhu, Bao-Ku[3]

第一作者：王凯凯

通讯作者：Wang, KK[1]

机构：[1]Xinxiang Univ, Coll Chem & Chem Engn, Xinxiang 453000, Henan, Peoples R China;[2]Xinxiang Univ, Med Coll, Xinxiang 453000, Henan, Peoples R China;[3]Zhejiang Univ, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310058, Zhejiang, Peoples R China

第一机构：新乡学院化学化工学院

通讯机构：[1]corresponding author), Xinxiang Univ, Coll Chem & Chem Engn, Xinxiang 453000, Henan, Peoples R China.|[110713]新乡学院化学化工学院;[11071]新乡学院;

年份：2019

卷号：56

期号：8

起止页码：2274-2280

外文期刊名：JOURNAL OF HETEROCYCLIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000480291100019)，CCR-EXPANDED(收录号:WOS:000480291100019)】；

基金：Acknowledgments. We are grateful to the National Natural Science Foundation of China (21801214) and the Higher Education Institution Key Research Project Plan of Henan Province of China (18A150014) for support of this research.

语种：英文

摘要：A rapid and highly efficient 1,3-dipolar [3 + 2] cycloaddition of nonstabilized azomethine ylides generated in situ with benzo[b]thiophene 1,1-dioxides as the dipolarophiles has been developed. The efficient method affords tricyclic pyrrolidine-fused benzo[b]thiophene 1,1-dioxide derivatives in high to excellent yields (up to 99%) with excellent diastereoselectivities (up to >25:1 dr) under mild reaction conditions. The structure of a typical product was confirmed by X-ray crystallography.