文献类型：期刊文献

英文题名：The synthesis of 2,6-diamino-9-B-D-arabinofuranosylpurine from vidarabine by the selective nitration and ammonolysis

作者：Xia, Ran[1];Sun, Li-Ping[2];Yang, Xi-Ning[3];Qu, Gui-Rong[3]

第一作者：夏然

通讯作者：Xia, R[1]

机构：[1]Xinxiang Univ, Dept Chem & Chem Engn, Xinxiang 453003, Peoples R China;[2]Xinxiang Univ, Sch Life Sci & Technol, Xinxiang 453003, Peoples R China;[3]Henan Normal Univ, Coll Chem & Chem Engn, Xinxiang 453007, Peoples R China

第一机构：新乡学院化学化工学院

通讯机构：[1]corresponding author), Xinxiang Univ, Dept Chem & Chem Engn, Xinxiang 453003, Peoples R China.|[110713]新乡学院化学化工学院;[11071]新乡学院;

年份：2015

卷号：39

期号：11

起止页码：665-667

外文期刊名：JOURNAL OF CHEMICAL RESEARCH

收录：;Scopus(收录号：2-s2.0-84954429268);WOS:【SCI-EXPANDED(收录号:WOS:000370354500012)，CCR-EXPANDED(收录号:WOS:000370354500012)】；

语种：英文

外文关键词：2,6-diamino-9-B-D-arabinofuranosylpurine; vidarabine; practical synthesis; late-stage nitration; ammonolysis

摘要：A practical synthesis of 2,6-diamino-9-B-D-arabinofuranosylpurine from the commercially available vidarabine is reported. Treatment of fully protected vidarabine with 2,2,2-trifluoroacetic anhydride and tetrabutylammonium nitrate introduced a -NO2 group in the C2 position in high yield. 2,6-Diamino-9-B-D-arabinofuranosylpurine was synthesised in three steps and 61% total yield after ammonolysis of the -NO2 accompanied by removal of the benzoyl groups.