文献类型：期刊文献

英文题名：A long-wavelength mitochondria-targeted fluorescent probe for imaging of peroxynitrite during dexamethasone treatment

作者：Tang, Jun[1];Li, Ziyi[1];Qiang, Chuchu[1];Han, Yan[1];Yang, Lifang[1];Zhu, Li[1];Dang, Tan[1];Chen, Gairong[1];Ye, Yong[2]

通讯作者：Tang, J[1]

机构：[1]Xinxiang Univ, Sch Chem & Mat Engn, Xinxiang 453003, Henan, Peoples R China;[2]Zhengzhou Univ, Coll Chem, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China

第一机构：新乡学院

通讯机构：[1]corresponding author), Xinxiang Univ, Sch Chem & Mat Engn, Xinxiang 453003, Henan, Peoples R China.|[11071]新乡学院;

年份：2023

卷号：292

外文期刊名：SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

收录：;EI(收录号：20230613568187);Scopus(收录号：2-s2.0-85147549973);WOS:【SCI-EXPANDED(收录号:WOS:001005231900001)】；

基金：This work was financially Supported by Xinxiang University Research Outstanding Doctoral Research Fund (No.1366020207) , Xin- xiang University Student Innovation and Entrepreneurship Training Program (No. 202211071025) and Higher Education Institution Key Research Project Plan of Henan Province of China (No.23A150043, 23B150018 and 22B480004) .

语种：英文

外文关键词：Mitochondria-targeted; ONOO-Fluorescence probe; Dexamethasone

摘要：Peroxynitrite (ONOO-), as a strong oxidizing reactive nitrogen substance (RNS), is generated endogenously by cells. Its visualization research is crucial to understand relevant disease processes. Herein, we reported a longwavelength mitochondria-targeted fluorescence "turn on" probe TL. The probe TL could react with ONOOby using 4-(Bromomethyl)benzeneboronic as a reactive site, which exhibited outstanding characteristics for detection of ONOO-, thus improving response time (about 50 s), sensitivity (DL, 10.1 nM), and emission wavelength (667 nm). Besides, TL displayed well mitochondria targeting and biological visualizing of exogenous and endogenous ONOO- in biological systems. Finally, TL was used to monitor high concentration of dexamethasone-induced an up-regulation of ONOO- . This indicated that TL has excellent potential to study the fluctuation of ONOO- in the physiological and pathological system.