文献类型：期刊文献

英文题名：Facile synthesis of tricyclic isoxazole-fused benzo[b]thiophene 1,1-dioxide derivatives via 1,3-dipolar cycloaddition

作者：Wang K.-K.; Li Y.-L.; Zhang W.; Zhang S.-S.; Qiu T.-T.; Ma X.

第一作者：Wang K.-K.

机构：[1]College of Chemistry and Chemical Engineering, Xinxiang University, Xinxiang, 453000, China;[2]Medical College, Xinxiang University, Xinxiang, 453000, China

第一机构：新乡学院化学化工学院

通讯机构：[1]College of Chemistry and Chemical Engineering, Xinxiang University, Xinxiang, 453000, China|[110713]新乡学院化学化工学院;[11071]新乡学院;

年份：2020

卷号：61

期号：23

外文期刊名：Tetrahedron Letters

收录：Scopus(收录号：2-s2.0-85084088651)

语种：英文

外文关键词：1,3-Dipolar cycloaddition; Benzo[b]thiophene 1,1-dioxide; Hydroximoyl chlorides; Isoxazole; [3+2] Annulation

摘要：A facile and efficient [3 + 2] 1,3-dipolar cycloaddition reaction of nitrile oxides generated in situ from hydroximoyl chlorides with benzo[b]thiophene 1,1-dioxides has been achieved for rapid access to tricyclic isoxazole-fused benzo[b]thiophene 1,1-dioxide derivatives in excellent yields (up to 98%) with high diastereoselectivities (dr > 19:1). The present process is characterized by mild reaction conditions and broad substrate scope. The conversion of the cycloadduct to other useful structure has also been achieved. The chemical structures of the typical compounds were confirmed by X-ray single-crystal structure analysis. ? 2020