文献类型：期刊文献

英文题名：STUDY ON A NEW PROCESS OF SYNTHESIS OF OMEPRAZOLE-LIKE AGENTS

作者：Jia, Ruoling[1]

第一作者：贾若凌

通讯作者：Jia, RL[1]

机构：[1]Xinxiang Univ, Coll Chem & Chem Engn, Xinxiang 453000, Peoples R China

第一机构：新乡学院化学化工学院

通讯机构：[1]corresponding author), Xinxiang Univ, Coll Chem & Chem Engn, Xinxiang 453000, Peoples R China.|[110713]新乡学院化学化工学院;[11071]新乡学院;

年份：2019

卷号：28

期号：4A

起止页码：3295-3299

外文期刊名：FRESENIUS ENVIRONMENTAL BULLETIN

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000467668200037)】；

语种：英文

外文关键词：Omeprazole; 2-Methyl-1H-benzimidazole; Anti-ulcerogenic activity; catalyst; molar yield

摘要：A new series of novel benzimidazole derivatives containing substituted pyrid-2-yl moiety and polyhydroxy sugar conjugated to the N-benzimidazole moiety has been synthesized and evaluated as orally bioavailable anti-inflammatory agents with anti-ulcerogenic activity. Effect of catalyst dosage, reaction temperature and reaction time on molar yield is investigated. Response surface methodology is applied to examine the relationship between each factor. The results show that reaction temperature is an important factor. Increasing catalyst dosage and reaction time can increase the molar yield. The optimal conditions are followed: temperature is 90 degrees C, reaction time is 12 h, and catalyst dosage is 5 g.