文献类型：期刊文献

英文题名：A NEW SYNTHESIS OF 2-CHLORO-2 '-DEOXYADENOSINE (CLADRIBINE), CDA)

作者：Xu, Shaohong[1];Yao, Peng[1];Chen, Gairong[1];Wang, Hui[1]

第一作者：徐绍红

通讯作者：Chen, GR[1]

机构：[1]Xinxiang Univ, Dept Chem & Chem Engn, Xinxiang City 453003, Henan Province, Peoples R China

第一机构：新乡学院化学化工学院

通讯机构：[1]corresponding author), Xinxiang Univ, Dept Chem & Chem Engn, Xinxiang City 453003, Henan Province, Peoples R China.|[110713]新乡学院化学化工学院;[11071]新乡学院;

年份：2011

卷号：30

期号：5

起止页码：353-359

外文期刊名：NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

收录：;Scopus(收录号：2-s2.0-79960827170);WOS:【SCI-EXPANDED(收录号:WOS:000294553500003)，CCR-EXPANDED(收录号:WOS:000294553500003)】；

基金：The authors are grateful to the Key Science and Technology Program of Henan Province, China (0624070006) and Scientific Research Program of Xinxiang City, China (09J049) for their support.

语种：英文

外文关键词：2-chloro-2 '-deoxyadenosine (Cladribine), CdA); new synthesis; Barton-McCombie reaction

摘要：A new efficient route for the synthesis of 2-chloro-2';-deoxyadenosine (Cladribine), CdA) has been developed. The key step of this method was selective deprotection of the acetyl group at the 2' position; the 3', 5' acetyl groups were not affected. This can be accomplished efficiently with hydroxylamine hydrochloride and sodium acetate in pyridine. The 2' hydroxyl group was removed by the Barton-McCombie reaction. Using this strategy, CdA was prepared in five steps and 31.0% yields.