文献类型：期刊文献

英文题名：Formal [3+2] cycloaddition of azomethine ylides generated in situ with unactivated cyclic imines: A facile approach to tricyclic imidazolines derivatives

作者：Wang, Kai-Kai[1];Li, Yan-Li[2];Wang, Zhan-Yong[1];Ma, Xueji[1];Mei, Ya-Lei[1];Zhang, Shan-Shan[1];Chen, Rongxiang[1]

第一作者：王凯凯

通讯作者：Chen, RX[1]

机构：[1]Xinxiang Univ, Coll Chem & Chem Engn, Xinxiang 453000, Henan, Peoples R China;[2]Xinxiang Univ, Coll Med, Xinxiang, Henan, Peoples R China

第一机构：新乡学院化学化工学院

通讯机构：[1]corresponding author), Xinxiang Univ, Coll Chem & Chem Engn, Xinxiang 453000, Henan, Peoples R China.|[110713]新乡学院化学化工学院;[11071]新乡学院;

年份：2020

卷号：57

期号：3

起止页码：1456-1463

外文期刊名：JOURNAL OF HETEROCYCLIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000504539500001)，CCR-EXPANDED(收录号:WOS:000504539500001)】；

基金：Funding of Henan Province University Student Innovation Program, Grant/Award Number: 201911071001; Higher Education Institution Key Research Project Plan of Henan Province of China, Grant/Award Numbers: 18A150014, 20B150019; National Natural Science Foundation of China, Grant/Award Numbers: 21702176, 21801214

语种：英文

摘要：A simple and efficient method for the synthesis of tricyclic imidazolines derivatives via [3 + 2] 1,3-dipolar cycloaddition between nonstabilized azomethine ylide generated in situ with unactivated cyclic imines is reported here. The method provided easy and mild access to various fused tricyclic hexahydroimidazo[5,1-a]isoquinolines in excellent yields (up to 96%). This protocol is simple and easy to handle.