文献类型：期刊文献

英文题名：Highly Efficient and Diastereoselective Construction of Tricyclic Pyrrolidine-Fused Benzo[b]thiophene 1,1-dioxide Derivatives via 1,3-Dipolar [3?+?2] Cycloaddition

作者：Wang K.-K.; Li Y.-L.; Ma G.-Y.; Yi M.-H.; Zhu B.-K.

第一作者：Wang K.-K.

机构：[1]College of Chemistry and Chemical Engineering, Xinxiang University, Xinxiang, 453000, China;[2]Medical College, Xinxiang University, Xinxiang, 453000, China;[3]MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Zhejiang University, Hangzhou, 310058, China

第一机构：新乡学院化学化工学院

通讯机构：[1]College of Chemistry and Chemical Engineering, Xinxiang University, Xinxiang, 453000, China|[110713]新乡学院化学化工学院;[11071]新乡学院;

年份：2019

卷号：56

期号：8

起止页码：2274-2280

外文期刊名：Journal of Heterocyclic Chemistry

收录：Scopus(收录号：2-s2.0-85067806187)

语种：英文

摘要：A rapid and highly efficient 1,3-dipolar [3?+?2] cycloaddition of nonstabilized azomethine ylides generated in situ with benzo[b]thiophene 1,1-dioxides as the dipolarophiles has been developed. The efficient method affords tricyclic pyrrolidine-fused benzo[b]thiophene 1,1-dioxide derivatives in high to excellent yields (up to 99%) with excellent diastereoselectivities (up to >25:1 dr) under mild reaction conditions. The structure of a typical product was confirmed by X-ray crystallography. ? 2019 Wiley Periodicals, Inc.