文献类型：期刊文献

英文题名：The practical acetylation of nucleosides using acetic anhydride/acetic acid as a reusable solvent

作者：Xia, Ran[1];Xia, Chao[1];Yang, Ying-Xing[1];Liu, Li-Jie[1];Chen, Lei-Shan[2];Sun, Li-Ping[2]

通讯作者：Chen, LS[1];Sun, LP[1]

机构：[1]Xinxiang Univ, Sch Pharm, Xinxiang, Henan, Peoples R China;[2]Xinxiang Univ, Sch Life Sci & Basic Med, Xinxiang 453003, Henan, Peoples R China

第一机构：新乡学院

通讯机构：[1]corresponding author), Xinxiang Univ, Sch Life Sci & Basic Med, Xinxiang 453003, Henan, Peoples R China.|[11071]新乡学院;

年份：2022

卷号：46

期号：4

外文期刊名：JOURNAL OF CHEMICAL RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000836818800001)，CCR-EXPANDED(收录号:WOS:000836818800001)】；

基金：The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: We thank the Key Scientific and Technical Projects of Henan Province (212102310333, 222102110403), the Training Plan for Young Key Teachers in Universities of Henan Province (202GGJS248), the Key Scientific and Technical Projects of Xinxiang City (GG2021016) and the Major Scientific and Technical Projects of Xinxiang City (21ZD008) for financial support.

语种：英文

外文关键词：acetylation; hydroxy group protection; late-stage modification; nucleosides; reusable solvent

摘要：The highly practical acetylation of free nucleosides is achieved using acetic anhydride/acetic acid as a reusable solvent and acetylating regent. A series of nucleosides, including ribosyl, deoxyribosyl, arabinosyl, acyclic and pyranosyl, and many clinical drugs were acetylated efficiently, even on large scale (200 g).