文献类型：期刊文献

英文题名：Toxicity of 8-Hydroxyquinoline in Cryprinus carpio Using the Acute Toxicity Test, Hepatase Activity Analysis and the Comet Assay

作者：Yan, Shuaiguo[1];Chen, Lili[2];Dou, Xiaofei[1];Qi, Meng[1];Du, Qiyan[1];He, Qiaoqiao[1];Nan, Mingge[1];Chang, Zhongjie[1];Nan, Ping[1]

第一作者：Yan, Shuaiguo

通讯作者：Nan, P[1]

机构：[1]Henan Normal Univ, Coll Life Sci, Xinxiang City 453007, Henan, Peoples R China;[2]Xinxiang Univ, Dept Biol Sci & Biotechnol, Xinxiang City 453007, Henan, Peoples R China

第一机构：Henan Normal Univ, Coll Life Sci, Xinxiang City 453007, Henan, Peoples R China

通讯机构：[1]corresponding author), Henan Normal Univ, Coll Life Sci, 46 East Jianshe Rd, Xinxiang City 453007, Henan, Peoples R China.

年份：2015

卷号：95

期号：2

起止页码：171-176

外文期刊名：BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY

收录：;EI(收录号：20152500943150);Scopus(收录号：2-s2.0-84937514547);WOS:【SCI-EXPANDED(收录号:WOS:000357481100006)】；

基金：This research was supported by Grants from the Specialized Research Fund for the Doctoral Program of Higher Education (20114104120006), Natural Science Foundation for the Youth of Henan Normal University (01046400063), the Natural Science Project of the Education Department of Henan Province (13B180076), the Key Subject of Ecology and Biology in Henan Province and the Undergraduates Innovating Experimentation Project of Henan Normal University.

语种：英文

外文关键词：Cryprinus carpio; 8-Hydroxyquinoline; Comet assay; GOT; GPT

摘要：To evaluate the environmental toxicity of 8-hydroxyquinoline (8-HOQ), an important industrial raw material found in China's major ornamental fish, Cryprinus carpio, using the acute toxicity test, hepatase activity analysis and the comet assay. The results indicated that 8-HOQ had significant acute toxicity in adult C. carpio with a 96 h-LC50 of 1.15 and 0.22 mg L-1 hepatic quinoline residues as assessed by HPLC. 8-HOQ also induced genotoxicity in the form of strand breaks in the DNA of hepatic cells as shown by the comet assay. With regard to physiological toxicity, 8-HOQ induced a decrease in the activities of hepatic GOT and GPT with increased exposure concentration and time. These data suggest that 8-HOQ may be toxic to the health of aquatic organisms when accidentally released into aquatic ecosystems. The data also suggest that the comet assay may be used in biomonitoring to determine 8-HOQ genotoxicity and hepatic GPT and GOT activities may be potential biomarkers of physiological toxicity.