文献类型：期刊文献

英文题名：Visualizing ClO- fluxes during homocysteine stress based on a nanoprobe

作者：Tang, Jun[1];Li, Ziyi[1];Li, Sheng[1];Yang, Lifang[1];Zhu, Li[1];Dang, Tan[1];Chen, Gairong[1];Ye, Yong[2]

通讯作者：Tang, J[1]

机构：[1]Xinxiang Univ, Sch Chem & Mat Engn, Xinxiang 453003, Henan, Peoples R China;[2]Zhengzhou Univ, Coll Chem, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China

第一机构：新乡学院

通讯机构：[1]corresponding author), Xinxiang Univ, Sch Chem & Mat Engn, Xinxiang 453003, Henan, Peoples R China.|[11071]新乡学院;

年份：2023

卷号：213

外文期刊名：DYES AND PIGMENTS

收录：;EI(收录号：20231213779279);Scopus(收录号：2-s2.0-85150440790);WOS:【SCI-EXPANDED(收录号:WOS:000950819000001)】；

基金：This work was financially Supported by Xinxiang University Research Outstanding Doctoral Research Fund (No.1366020207) , Xin- xiang University Student Innovation and Entrepreneurship Training Program (No. 202211071025) and Higher Education Institution Key Research Project Plan of Henan Province of China (No.23A150043, 23B150018 and 22B480004) .

语种：英文

外文关键词：Nanoprobe; Hcy; Atherosclerosis (AS); Oxidation stress; ClO-

摘要：As one of important indicators of atherosclerosis (AS), excess homocysteine (Hcy), could cause oxidation stress, thus leading to inflammation and tissue damage. Hypochlorous acid/hypochlorite (HOCl/OCl-), as an important reactive oxygen species, is speculated to be an indicator of AS caused by Hcy-inducated. Here, a fluorescence nanoprobe LR NPs based on the assembly of pluronic F-127 and probe TR was developed for ClO- detection and imaging during Hcy stress. As expected, LR NPs showed good selectivity and sensitivity for ClO- detection. LR NPs can visualize the fluxes of HClO/ClO- during the stimulation of Hcy induce AS in real time, which demonstrated HClO/ClO- could be performed as an indicator of AS.