文献类型：期刊文献

英文题名：The synthesis of nebularine and its analogs via oxidative desulfuration in aqueous nitric acid

作者：Xia, Ran[1];Sun, Li-Ping[1];Qu, Gui-Rong[2]

第一作者：夏然

通讯作者：Xia, R[1]

机构：[1]Xinxiang Univ, Sch Chem & Chem Engn, Sch Life Sci & Technol, Eastern Jinsui Rd, Xinxiang City 453003, Henan Province, Peoples R China;[2]Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang City, Henan Province, Peoples R China

第一机构：新乡学院化学化工学院|新乡学院生命科学技术学院

通讯机构：[1]corresponding author), Xinxiang Univ, Sch Chem & Chem Engn, Sch Life Sci & Technol, Eastern Jinsui Rd, Xinxiang City 453003, Henan Province, Peoples R China.|[110713]新乡学院化学化工学院;[11071]新乡学院;[1107115]新乡学院生命科学技术学院;

年份：2017

卷号：192

期号：1

起止页码：88-91

外文期刊名：PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

收录：;Scopus(收录号：2-s2.0-84994152019);WOS:【SCI-EXPANDED(收录号:WOS:000392648000016)，CCR-EXPANDED(收录号:WOS:000392648000016)】；

基金：The authors thank the National Natural Science Foundation of China (21602189), Key Scientific Research Projects of Henan Province (16A150042, 16A180035), Key scientific and technological projects of Xinxiang City (CXGG16037), and the Science and Technology Innovation Fund of Xinxiang University (15ZP06) for financial support.

语种：英文

外文关键词：Nebularine; desulfuration; base modification; nucleoside synthesis

摘要：The synthesis of nebularine and its analogs has been achieved via oxidative desulfuration in H2O for the first time. With 50% HNO3 as an oxidant and solvent, 18 products were obtained in good yields (70%-94%). The oxidative desulfuration system could tolerate different functional groups including fluoro, chloro, amino, alkyl, allyl, ribosyl, deoxyribosyl, and arabinofuranosyl groups. More importantly, the drug nebularine could be obtained successfully on a 20g scale, which made this route more attractive for industrial applications.