文献类型：期刊文献

英文题名：Facile Synthesis of Tricyclic 1,2,4-Oxadiazolines-Fused Tetrahydro-Isoquinolines from Oxime Chlorides with 3,4-Dihydroisoquinoline Imines

作者：Wang, Kaikai[1,2];Li, Yanli[3];Zhang, Wei[1];Chen, Rongxiang[1];Ma, Xueji[1,2];Wang, Mingyue[1];Zhou, Nan[1]

第一作者：Wang, Kaikai

通讯作者：Chen, RX[1];Ma, XJ[1];Ma, XJ[2]

机构：[1]Xinxiang Univ, Sch Pharm, Xinxiang 453000, Henan, Peoples R China;[2]Key Lab Nanocarbon Modified Film Technol Engn Hen, Xinxiang 453000, Henan, Peoples R China;[3]Xinxiang Univ, Med Coll, Xinxiang 453000, Henan, Peoples R China

第一机构：新乡学院

通讯机构：[1]corresponding author), Xinxiang Univ, Sch Pharm, Xinxiang 453000, Henan, Peoples R China;[2]corresponding author), Key Lab Nanocarbon Modified Film Technol Engn Hen, Xinxiang 453000, Henan, Peoples R China.|[11071]新乡学院;

年份：2022

卷号：27

期号：10

外文期刊名：MOLECULES

收录：;Scopus(收录号：2-s2.0-85131108721);WOS:【SCI-EXPANDED(收录号:WOS:000801498400001)】；

基金：This research was funded by NSFC (21801214 and 21702176), the Program for Youth Backbone Teacher Training in University of Henan Province (2021GGJS163), and the Natural Science Foundation of Henan Province (202300410016).

语种：英文

外文关键词：1; 2; 4-oxadiazolines; oxime chlorides; cycloaddition; cyclic imines

摘要：A mild and efficient strategy for the synthesis of tricyclic 1,2,4-oxadiazolines-fused tetrahydro-isoquinolines derivatives via [3 + 2] cycloaddition reaction is reported. The reactions provided the functionalized tricyclic 1,2,4-oxadiazolines in high yields (up to 96%). This protocol is simple and easy to handle. Moreover, a gram-scale experiment further highlights the synthetic utility. The chemical structure of the product was determined by X-ray single-crystal structure analysis. A possible mechanism for this transformation is proposed to explain the reaction process.