文献类型：期刊文献

中文题名：犊牛磺胺中毒的病理形态学观察

英文题名：Study on Pathologic Morphology on Calves with Sulfonamide Toxicosis

作者：潘耀谦[1];王选年[2];朱广蕊[1];夏银可[1];王青[3];李鹏[2];岳锋[2];黄薇[1];勾晓晶[1]

第一作者：潘耀谦

机构：[1]河南科技学院动物科学学院;[2]新乡学院生物技术研究中心;[3]河南科技学院实验中心

第一机构：河南科技学院动物科学学院,河南新乡453003

年份：2011

卷号：32

期号：9

起止页码：69-72

中文期刊名：动物医学进展

外文期刊名：Progress in Veterinary Medicine

收录：CSTPCD;;北大核心:【北大核心2008】；CSCD:【CSCD_E2011_2012】；

语种：中文

中文关键词：犊牛;磺胺;中毒;肾脏;肝脏

外文关键词：calf; sulfonamide; poisoning; kidney; liver

摘要：为了解犊牛磺胺中毒的病理形态学变化特点,对2头因磺胺中毒而死亡的犊牛进行了详细的病理学研究。结果表明,犊牛磺胺中毒的病理性损伤主要发生于肾脏和肝脏。宏观检查可见,肾脏肿胀,色泽变淡,皮质增宽,肾盂有多量豆腐渣样物质。肝脏肿胀,淡橘红色,质地脆易碎。微观检查可见,近曲小管上皮细胞肿胀,核浓缩,染色不良,大量上皮细胞脱落。病变严重时,近曲小管上皮细胞的核溶解消失,或仅见核残迹。坏死的上皮细胞凝集在一起,形成典型的凝固性坏死。在坏死的肾小管之间弥散有大量红细胞。远曲肾小管的病变较轻,集合肾小管的管腔中有大量透明管型形成。肝脏的中央静脉和肝窦扩张,充满大量红细胞,肝细胞肿大,有的胞浆中有边缘不整的空泡,发生水泡变性;而大部分肝细胞则呈细网状,发生了糖原溶解。此外,脾脏的白髓和淋巴结中的淋巴小结发育不良,没有形成完整的淋巴滤泡,说明磺胺中毒可能对体液免疫有一定的影响。结果表明,犊牛的磺胺中毒可引起近曲小管的凝固性坏死和集合管中的透明管型形成,导致肝细胞发生水泡变性和糖原溶解。
In order to understand the characteristics of pathomorphological changes in sulfonamide poisoning calves,two calves died with sulfonamide poisoning were particularly researched in this study.The results showed that the pathological damages of sulfonamide poisoning calves mainly occur in kidney and liver.Kidneys are swelling,lighting in colour and broadening in renal cortex.There are many substances of soybean curb-like residue in renal pelvis.Liver is swelling,pale orange in colour,fragile and brittle in texture.Microscopic examination showed that epithelial cells of proximal convoluted tubule are swelling,with a concentrating nucleus and dyeing bad.A lot of epithelial cells shed off.When lesions are severe,the lysing nucleus or only nuclear remnants are found in the epithelial cell of proximal convoluted tubular.Necrotic epithelial cells are agglutinated together to form typical coagulation necrosis.There are a large number of red blood cells diffusive among necrotic renal tubules.The lesions of distal tubules are lighter.There are a lot of hyaline casts in collecting tubules.The central vein and sinus in liver are expansion and full of number of red blood cells.Hepatic cells are swelling and vacuolar degeneration.Most hepatic cells are looked like mesh,there are glycogen dissolve.In addition,lymph nodules are dysplasia,and no complete lymphoid follicles are found in spleen and lymph nodes.It may be explained to affect humoral immunity in a certain extent about sulfonamide poisoning.Conclusion： the calf sulfonamide poisoning can cause coagulation necrosis in proximal convoluted tubules and formation of hyaline cast in collecting tubules,and generate vacuolar degeneration and glycogen dissolve in hepatic cells.