文献类型：期刊文献

英文题名：1,3-Dipolar cycloaddition of isatin: N, N ′-cyclic azomethine imines with α,β-unsaturated aldehydes catalyzed by DBU in water

作者：Wang, Zhan-Yong[1]; Yang, Ting[2]; Chen, Rongxiang[1]; Ma, Xueji[1]; Liu, Huan[1]; Wang, Kai-Kai[1]

第一作者：王占勇

通讯作者：Wang, Kai-Kai

机构：[1] College of Chemistry and Chemical Engineering, Xinxiang University, Xinxiang, 453003, China; [2] Medical College, Xinxiang University, Xinxiang, 453003, China

第一机构：新乡学院化学化工学院

年份：2020

卷号：10

期号：41

起止页码：24288-24292

外文期刊名：RSC Advances

收录：EI(收录号：20202808918062);Scopus(收录号：2-s2.0-85087545275)

基金：We gratefully acknowledge the National Natural Science Foundation of China (21801214, 21702176), Foundation of University Student Innovation Program (201911071001, S201911071007).

语种：英文

外文关键词：Cycloaddition - Stereoselectivity

摘要：A simple and green procedure was established by [3 + 3] cycloaddition reaction of isatin derived cyclic imine 1,3-dipoles with α,β-unsaturated aldehydes, giving the desired spiro heterocyclic oxindoles with aza-quaternary centers in good yields and diastereoselectivities. It should be noted that water can be employed as a suitable solvent for the improvement of diastereoselectivity. ? The Royal Society of Chemistry.