文献类型：期刊文献

英文题名：Nano gamma-Fe2O3-supported fluoroboric acid: a novel magnetically recyclable catalyst for the synthesis of 12-substituted-benzo[h][1,3]dioxolo[4,5-b]acridine-10,11-diones as potent antitumor agents

作者：Yang, Xiaojuan[1];Zhang, Chong[2];Wu, Liqiang[2]

第一作者：杨晓娟

通讯作者：Wu, LQ[1]

机构：[1]Xinxiang Univ, Coll Chem & Chem Engn, Xinxiang 453003, Henan, Peoples R China;[2]Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Peoples R China

第一机构：新乡学院化学化工学院

通讯机构：[1]corresponding author), Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Peoples R China.

年份：2015

卷号：5

期号：32

起止页码：25115-25124

外文期刊名：RSC ADVANCES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000351354000035)】；

基金：We are pleased to acknowledge the financial support from Xinxiang University.

语种：英文

摘要：Nano gamma-Fe2O3-supported fluoroboric acid was synthesized as a novel magnetic catalyst and characterized. The nanoparticle reagent was obtained with good loading levels and has been successfully used for the efficient and selective synthesis of 12-substituted-benzo[h][1,3] dioxolo[4,5-b]acridine-10,11-diones. The catalyst is quantitatively recovered with an external magnet and can be reused for six cycles with almost consistent activity. In addition, all the synthetic derivatives were fully characterized using spectral data and evaluated for their antitumor activity on human hepatoma cells (HepG2) and Henrietta Lacks strain of cancer cells (HeLa). Among the 19 new compounds screened, 12-(2-fluorophenyl)-benzo[h][1,3]dioxolo[ 4,5-b] acridine-10,11-dione (4d) has pronounced activity.