文献类型：期刊文献

英文题名：NHC-Catalyzed Oxidative Annulation of alpha,beta-unsaturated Aldehydes with Benzyl Ketones: Direct Access to 4,5,6-Trisubstituted Dihydropyranones

作者：Wang, Zhan-Yong[1];Liu, Qingling[1];Wang, Kai-Kai[1];Liu, Menghan[1];Han, Yafei[1];Sun, Aili[1];Ma, Xueji[1]

通讯作者：Sun, AL[1];Ma, XJ[1]

机构：[1]Xinxiang Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China

第一机构：新乡学院

通讯机构：[1]corresponding author), Xinxiang Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China.|[11071]新乡学院;

年份：2021

卷号：10

期号：4

起止页码：766-770

外文期刊名：ASIAN JOURNAL OF ORGANIC CHEMISTRY

收录：;Scopus(收录号：2-s2.0-85101844309);WOS:【SCI-EXPANDED(收录号:WOS:000624033200001)，CCR-EXPANDED(收录号:WOS:000624033200001)】；

基金：We gratefully acknowledge the National Natural Science Foundation of China (21702176 and 21801214), Foundation of University Student Innovation Program (S202011071012).

语种：英文

外文关键词：lactonization; dihydropyranones; NHC-catalyzed; Michael addition; benzyl ketones

摘要：A novel and efficient access to polysubstituted dihydropyranones was developed by N-heterocyclic carbene catalyzed annulation reaction of alpha,beta-unsaturated aldehydes and benzyl ketones under oxidative conditions. Various alpha,beta-unsaturated aldehydes with long-chain aliphatic and aromatic substitution groups were compatible in this transformation, giving the corresponding products in good to excellent yields under mild conditions. This strategy features simple and readily available materials and mild reaction conditions and provides a green and practical method for the rapid synthesis of functionalized dihydropyranones.