文献类型：期刊文献

中文题名：鼠源成纤维细胞生长因子-21的长效降糖效果

英文题名：The long lasting effect of the murine fibroblast growth factor-21 on blood glucose control of diabetic animals

作者：赵景壮[1];孙国鹏[2];叶贤龙[1];李晋南[3];任桂萍[1];王文飞[1];刘铭瑶[1];李德山[1]

第一作者：赵景壮

机构：[1]东北农业大学生命科学学院;[2]新乡学院生命科学与技术系;[3]中国水产科学院黑龙江水产研究所

第一机构：东北农业大学生命科学学院,黑龙江哈尔滨150030

年份：2013

卷号：48

期号：3

起止页码：352-358

中文期刊名：药学学报

外文期刊名：Acta Pharmaceutica Sinica

收录：MEDLINE(收录号：23724647);CSTPCD;;Scopus(收录号：2-s2.0-84877324057);北大核心:【北大核心2011】；CSCD:【CSCD2013_2014】；PubMed;

基金：黑龙江省发展和改革委员会重大前期项目(黑发改项目[2011]1570号);黑龙江省博士后科研启动基金项目(LBH-Q09162);黑龙江省教育厅科学技术研究项目(12521z004)

语种：中文

中文关键词：糖尿病;成纤维细胞生长因子-21;db;db小鼠;血糖调控

外文关键词：diabetes; FGF-21; db/db mice; blood glucose regulation

摘要：胰岛素是糖尿病患者常用的降糖药物,但胰岛素药效短,即使长效胰岛素也不能达到令人满意的效果。成纤维细胞生长因子(FGF)-21是近期发现的一种不依赖于胰岛素但具有降糖作用的潜力型药物。通过检测mFGF-21治疗后2型糖尿病db/db小鼠血糖和糖基化血红蛋白的变化,研究其对2型糖尿病动物是否有长期、稳定的降糖效果。一天一次治疗模型动物结果表明,mFGF-21可以有效地将模型动物血糖调控在正常水平,维持至少24 h,并且随着mFGF-21剂量的增加对血糖的调控机制更加快速、持久。两天注射一次mFGF-21,虽然模型动物血糖下降缓慢,但是长期治疗后仍能降至正常水平,在停止给药后24 h之内其血糖仍能稳定维持在正常水平;其糖基化血红蛋白水平与胰岛素阳性对照组相比显著下降。结果提示,FGF-21有望成为能够替代胰岛素的长效的降糖药物。
Insulin is the most common medicine used for diabetic patients, unfortunately, its effective time is short, even the long-acting insulin cannot obtain a satisfactory effect. Fibroblast growth factor （FGF）-21 is a recently discovered glucose mediator and expected to be a potential anti-diabetic drug that does not rely on insulin. In this study, db/db mice were used as the type 2 diabetic model to examine whether mFGF-21 has the long-term blood lowering effect on the animal model. The results showed that mFGF-21 could stably maintain the blood glucose at normal level for a long-term in a dose-dependent manner. Administration of mFGF-21 once a day with three doses （0.125, 0.25 and 0.5 mg-kg-1） could maintain blood glucose of the model animals at normal level for at least 24 h. Administration of mFGF-2 l every two days with the same doses could maintain blood glucose of the model animals at normal level for at least 48 h, although it took longer time for blood glucose to reach to normal level depending on doses used （twenty injections for 0.125 mg .kg-1 and 0.25 mg.kg-l doses, ten injections for 0.5 mg.kg-1 dose）. Surprisingly, the blood glucose of the treated model animals stillmaintained at normal level for 24 h after the experiment terminated. Glycosylated hemoglobin level of the animals treated with mFGF-21, which represented long term glucose status, decreased significantly compared to the control group and the insulin group. The results suggest that FGF-21 has potential to become a long-acting and potent anti-diabetic drug.