详细信息
文献类型:期刊文献
中文题名:前列腺癌与表观遗传修饰
英文题名:Prostate cancer and epigenetic modification
作者:席兴字[1]
第一作者:席兴字
机构:[1]新乡学院教科系
第一机构:新乡学院教育科学学院
年份:2010
期号:3
起止页码:374-376
中文期刊名:生命的化学
外文期刊名:Chemistry of Life
收录:CSTPCD;;北大核心:【北大核心2008】;CSCD:【CSCD_E2011_2012】;
语种:中文
中文关键词:前列腺癌;表观遗传修饰;PcG蛋白质;雄激素受体;微RNA
外文关键词:prostate cancer; epigenetic modification; PcG protein; androgen receptor; microRNA
摘要:前列腺癌是威胁男性健康的主要恶性肿瘤之一,近年来其发病率呈上升趋势。前列腺癌的发生是遗传学因素和表观遗传因素共同作用的结果。本文简要综述了PcG(polycomb group)蛋白质、AR共调节子和微RNA(microRNA)等表观遗传修饰方式与前列腺癌的联系,希望有助于前列腺癌的诊断和治疗。
Prostate cancer is one of the most frequent cancers in males,the incidence of which has been increased in recent years.The development and progression of prostate cancer,like other human cancers,is driven by the interplay of genetic and epigenetic changes.In this paper,the link between polycomb group(PcG) proteins,androgen receptor coregulators,microRNA and prostate cancer was summarized,which may become highly useful for diagnostics and therapy of prostate cancer.
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