文献类型：期刊文献

英文题名：Rhodium-Catalyzed Annulation of α-Imino Carbenes with α,β-Unsaturated Ketones: Construction of Multisubstituted 2,3-Dihydropyrrole/pyrrole Rings

作者：Ma, Xueji[1]; Liu, Li[1]; Wang, Jiaying[1]; Xi, Xianglin[1]; Xie, Xuemei[1]; Wang, Hangxiang[2]

第一作者：马学骥

通讯作者：Wang, Hangxiang

机构：[1] Department of Chemistry and Chemical Engineering, Xinxiang University, Xinxiang, 453003, China; [2] First Affiliated Hospital, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation of Zhejiang Province, School of Medicine, Zhejiang University, Hangzhou, 310003, China

第一机构：新乡学院化学化工学院

年份：2018

卷号：83

期号：23

起止页码：14518-14526

外文期刊名：Journal of Organic Chemistry

收录：EI(收录号：20184806142102);Scopus(收录号：2-s2.0-85057029037)

基金：The authors thank the financial support from the National Natural Science Foundation of China (21702176, 81773193, and 81571799) and the Key Scientific Research Project of Henan Province (17A150046).

语种：英文

外文关键词：Chemistry - Organic compounds

摘要：An efficient annulation of α-imino rhodium carbenes with α,β-unsaturated ketones has been developed to generate multisubstituted 2,3-dihydropyrrole derivatives. Using the optimized catalyst, this approach is compatible with both cyclic and normal linear α,β-unsaturated ketones. Further detosylation in the presence of base could produce multisubstituted pyrroles. The new method has the potential to enable the rapid construction of bioactive molecules containing pyrrole rings. ? 2018 American Chemical Society.