文献类型：期刊文献

英文题名：Synthesis of 1,3,5-trisubstituted pyrazoles via 1,3-dipolar cycloaddition of nitrile imines with ninhydrin-derived Morita-Baylis-Hillman carbonates

作者：Wang, Kai-Kai[1]; Li, Yan-Li[2]; Jing, Jun[1]; Chen, Rongxiang[1]; Zhao, Na-Na[1]; Li, Zhi-Hui[1]; Wang, Ming-Yue[1]; Ji, Shuo-Ke[1]

机构：[1] School of Pharmacy, Xinxiang University, Xinxiang, 453000, China; [2] Medical College, Xinxiang University, Xinxiang, 453000, China

第一机构：新乡学院

通讯机构：[1]School of Pharmacy, Xinxiang University, Xinxiang, 453000, China|[11071]新乡学院;

年份：2022

卷号：20

期号：34

起止页码：6923-6930

外文期刊名：Organic and Biomolecular Chemistry

收录：EI(收录号：20223512673805);Scopus(收录号：2-s2.0-85136901667)

语种：英文

外文关键词：Cycloaddition - Rate constants

摘要：An effective synthetic method for 1,3,5-trisubstituted pyrazoles via 1,3-dipolar cycloaddition reaction has been developed. This reaction could smoothly proceed between ninhydrin-derived Morita-Baylis-Hillman carbonates and nitrilimines to provide a wide scope of differently substituted pyrazoles in high yields (up to 95%). In addition, the reaction mechanism was also proposed to explain its regioselectivity. ? 2022 The Royal Society of Chemistry.