文献类型：期刊文献

英文题名：Highly efficient and diastereoselective construction of substituted pyrrolidines bearing a quaternary carbon center via 1,3-dipolar cycloaddition

作者：Wang, Kai-Kai[1];Li, Yan-Li[2];Xiao-Qian, Shuai[3];Chen, Rongxiang[1];Sun, Aili[1];Wang, Zhan-Yong[1]

通讯作者：Chen, RX[1];Wang, ZY[1]

机构：[1]Xinxiang Univ, Sch Pharm, Key Lab Nanocarbon Modified Film Technol Engn Hen, Xinxiang, Peoples R China;[2]Xinxiang Univ, Med Coll, Xinxiang, Henan, Peoples R China;[3]Xinxiang Sci & Technol Assoc, Xinxiang, Henan, Peoples R China

第一机构：新乡学院

通讯机构：[1]corresponding author), Xinxiang Univ, Sch Pharm, Xinxiang 453000, Henan, Peoples R China.|[11071]新乡学院;

年份：0

外文期刊名：JOURNAL OF HETEROCYCLIC CHEMISTRY

收录：;Scopus(收录号：2-s2.0-85130031554);WOS:【SCI-EXPANDED(收录号:WOS:000794130800001)，CCR-EXPANDED(收录号:WOS:000794130800001)】；

基金：Key Scientific and Technological Project of Xinxiang, Grant/Award Number: 21ZD010; National College Students Innovation and Entrepreneurship Training Program, Grant/Award Numbers: 202111071021, 202111071025; Key Scientific Research Project of Colleges and Universities in Henan Province, Grant/Award Numbers: 22B150015, 20B150019, 18A150014; Natural Science Foundation of Henan Province, Grant/Award Number: 202300410016; Program for Youth Backbone Teacher Training at the University of Henan Province, Grant/Award Number: 2021GGJS163; National Natural Science Foundation of China, Grant/Award Number: 21801214

语种：英文

摘要：A general approach to substituted pyrrolidines via [3 + 2] cycloaddition between nonstabilized azomethine ylides and cyanosulfones was developed. The efficient method provides a series of substituted pyrrolidines bearing a quaternary carbon center in high yields (up to 98%) excellent diastereoselectivities (up to >25:1 dr) under ambient reaction conditions.