文献类型：期刊文献

英文题名：1,3-Dipolar cycloaddition reactions of azomethine ylides with seven-membered cyclic N-sulfony imines access to polycyclic sulfonamides

作者：Wang K.-K.; Li Y.-L.; Lv Y.-J.; Shen R.-H.; Zhao W.; Chen R.

第一作者：Wang K.-K.

机构：[1]School of Pharmacy, Xinxiang University, Xinxiang, 453000, China;[2]Medical College, Xinxiang University, Xinxiang, 453000, China;[3]Xinxiang Tuoxin Pharmaceutical Co., Ltd, Xinxiang, 453000, China

第一机构：新乡学院

通讯机构：[1]School of Pharmacy, Xinxiang University, Xinxiang, 453000, China|[11071]新乡学院;

年份：2021

卷号：77

外文期刊名：Tetrahedron

收录：Scopus(收录号：2-s2.0-85096572686)

语种：英文

外文关键词：1,3-Dipolar cycloaddition; Azomethine ylides; Cyclic N-sulfony imines; Polycyclic sulfonamides; [3+2] annulation

摘要：A straightforward and efficient strategy for the synthesis of novel functionalized polycyclic sulfonamides containing ε-sultams motif under metal-free catalysis via [3 + 2] 1,3-dipolar cycloaddition reactions of azomethine ylides generated in situ with seven-membered cyclic N-sulfony imines has been achieved. The present process was carried out under mild reaction conditions to give polycyclic sulfonamides in high yield (up to 95%). Additionally, the conversion of the cycloadduct to other useful structure has also been developed. The structure of the typical product was clearly established by X-ray crystallography. ? 2020 Elsevier Ltd