文献类型：期刊文献

英文题名：Catalyst-Free Synthesis of 2,3-Benzodiazepines via Tetrahydrodiazirino[3,1-a]isoquinoline Reacts with Sulfonyl Chlorides

作者：Wang, Kaikai[1];Li, Yanli[2];Wang, Xiaoyu[1];Zhu, Baoku[1,3]

第一作者：王凯凯

通讯作者：Wang, KK[1]

机构：[1]Xinxiang Univ, Coll Chem & Chem Engn, Xinxiang 453000, Henan, Peoples R China;[2]Xinxiang Univ, Med Coll, Xinxiang 453000, Henan, Peoples R China;[3]Zhejiang Univ, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310058, Zhejiang, Peoples R China

第一机构：新乡学院化学化工学院

通讯机构：[1]corresponding author), Xinxiang Univ, Coll Chem & Chem Engn, Xinxiang 453000, Henan, Peoples R China.|[110713]新乡学院化学化工学院;[11071]新乡学院;

年份：2019

卷号：4

期号：12

起止页码：3340-3343

外文期刊名：CHEMISTRYSELECT

收录：;Scopus(收录号：2-s2.0-85063648700);WOS:【SCI-EXPANDED(收录号:WOS:000462781100012)】；

基金：We are grateful for financial support from the National Natural Science Foundation of China (21801214) and the Higher Education Institution Key Research Project Plan of Henan Province of China (18A150014).

语种：英文

外文关键词：2; 3-Benzodiazepines; Catalyst-free; Sulfonyl Chlorides; Heterocycles; Azomethine imines

摘要：An unexpected process from tetrahydrodiazirino[3,1-a]isoquinolines and diversified sulfonyl chlorides RSO2Cl (R=aryl, alkyl) to deliver highly yields 4,5-dihydro-3H-benzo[d][1,2]diazepine skeleton compounds was disclosed via N-insertion ring-opening reaction. The structural framework of 2,3-benzodiazepines is unambiguously confirmed by single-crystal X-ray crystallographic analysis. The present protocol features mild reaction conditions, high yields and feasibility of large-scale synthesis and catalyst-free access to benzo[2,3]diazepines skeleton. In contrast, azomethine imines were produced by employing tetrahydrodiazirino[3,1-a]isoquinoline reacts with aroyl chlorides under the same conditions.