文献类型：期刊文献

英文题名：Formal [3 + 2] cycloaddition of azomethine ylides generated in situ with unactivated cyclic imines: A facile approach to tricyclic imidazolines derivatives

作者：Wang K.-K.; Li Y.-L.; Wang Z.-Y.; Ma X.; Mei Y.-L.; Zhang S.-S.; Chen R.

第一作者：Wang K.-K.

机构：[1]College of Chemistry and Chemical Engineering, Xinxiang University, Xinxiang, China;[2]Medical College, Xinxiang University, Xinxiang, China

第一机构：新乡学院化学化工学院

通讯机构：[1]College of Chemistry and Chemical Engineering, Xinxiang University, Xinxiang, China|[110713]新乡学院化学化工学院;[11071]新乡学院;

年份：2020

卷号：57

期号：3

起止页码：1456-1463

外文期刊名：Journal of Heterocyclic Chemistry

收录：Scopus(收录号：2-s2.0-85077386158)

语种：英文

摘要：A simple and efficient method for the synthesis of tricyclic imidazolines derivatives via [3 + 2] 1,3-dipolar cycloaddition between nonstabilized azomethine ylide generated in situ with unactivated cyclic imines is reported here. The method provided easy and mild access to various fused tricyclic hexahydroimidazo[5,1-a]isoquinolines in excellent yields (up to 96%). This protocol is simple and easy to handle. ? 2019 Wiley Periodicals, Inc.