文献类型：期刊文献

英文题名：Synthesis and cytotoxic activity of tanshinone I derivatives having azacyclo moiety

作者：Wu, Liqiang[1]; Yang, Xiaojuan[2]

第一作者：Wu, Liqiang

通讯作者：Wu, L.

机构：[1] School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China; [2] College of Chemistry and Chemical Engineering, Xinxiang University, Xinxiang, Henan, China

第一机构：School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China

通讯机构：[1]School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China

年份：2014

卷号：6

期号：2

起止页码：442-445

外文期刊名：Journal of Chemical and Pharmaceutical Research

收录：EI(收录号：20141117465567);Scopus(收录号：2-s2.0-84903368571)

语种：英文

外文关键词：Pharmacodynamics

摘要：Three-component coupling of 3-amino-1,2,4-triazole, aldehydes and 3-hydroxy-8- methyl-1,4-phenanthrenequinone has been achieved using a catalytic amount of p-TsOH under solvent-free conditions to produce a novel series of tanshinone I derivatives having azacyclo in good yields and with high regioselectivity. These compounds are found to exhibit potent antitumoral properties.