文献类型：期刊文献

英文题名：EFFICIENT SYNTHESIS OF CLADRIBINE via the METAL-FREE DEOXYGENATION

作者：Xia, Ran[1];Chen, Lei-Shan[1]

第一作者：夏然

通讯作者：Xia, R[1]

机构：[1]Xinxiang Univ, Dept Chem & Chem Engn, Xinxiang City, Henan Province, Peoples R China

第一机构：新乡学院化学化工学院

通讯机构：[1]corresponding author), Xinxiang Univ, Dept Chem & Chem Engn, Xinxiang City, Henan Province, Peoples R China.|[110713]新乡学院化学化工学院;[11071]新乡学院;

年份：2015

卷号：34

期号：10

起止页码：729-735

外文期刊名：NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

收录：;Scopus(收录号：2-s2.0-84945978029);WOS:【SCI-EXPANDED(收录号:WOS:000363691900005)，CCR-EXPANDED(收录号:WOS:000363691900005)】；

语种：英文

外文关键词：Cladribine; metal-free; deoxygenation; nucleoside synthesis

摘要：The efficient synthesis of cladribine via the metal-free deoxygenation was developed. Using (Bu4N)(2)S2O8/HCO2Na instead of Bu3SnH/AIBN as deoxygenation system, cladribine could be obtained with good yield and even on tens of grams scales. The intermediates and product could be purified by simple work-up process and chromatography was avoided, which showed the good future for industrial applications.