文献类型：期刊文献

英文题名：A copper iodide-catalyzed coupling reaction of benzofuran-3(2H)-ones with amines: an approach to alpha-ketoamides

作者：Chen, Rongxiang[1];Jia, Ruo-Ling[1];Li, Wenbo[2];Zhao, Wei[1];Wang, Kai-Kai[1];Wang, Zhan-Yong[1];Ma, Xueji[1];Dai, Wei[1];Sun, Aili[1]

第一作者：Chen, Rongxiang

通讯作者：Wang, KK[1];Sun, AL[1]

机构：[1]Xinxiang Univ, Sch Pharm, Xinxiang 453000, Henan, Peoples R China;[2]Xinxiang Univ, Sch Chem & Mat Engn, Xinxiang 453000, Henan, Peoples R China

第一机构：新乡学院

通讯机构：[1]corresponding author), Xinxiang Univ, Sch Pharm, Xinxiang 453000, Henan, Peoples R China.|[11071]新乡学院;

年份：2021

卷号：19

期号：24

起止页码：5294-5297

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000657786000001)，CCR-EXPANDED(收录号:WOS:000657786000001)】；

基金：We gratefully acknowledge the financial support from the National Natural Science Foundation of China (21702176, 21801214), the Natural Science Foundation of Henan (202300410016) and the funding of the Henan Province University Student Innovation Program (S202011071006).

语种：英文

摘要：A CuI-catalyzed coupling reaction of benzofuran-3(2H)-ones with amines has been well established for the direct synthesis of alpha-ketoamides. This process involves C-O bond cleavage and CvO/C-N bond formation. Mechanism studies indicated that this alpha-ketoamide formation reaction may involve a free radical process.