文献类型：期刊文献

英文题名：L-Proline catalyzed three-component synthesis of para-naphthoquinone-4-aza-podophyllotoxin hybrids as potent antitumor agents

作者：Yang, Xiaojuan[1];Zhang, Chong[2];Wu, Liqiang[2]

第一作者：杨晓娟

通讯作者：Wu, LQ[1]

机构：[1]Xinxiang Univ, Coll Chem & Chem Engn, Xinxiang 453003, Henan, Peoples R China;[2]Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Peoples R China

第一机构：新乡学院化学化工学院

通讯机构：[1]corresponding author), Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Peoples R China.

年份：2015

卷号：5

期号：24

起止页码：18945-18951

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20150900570391);Scopus(收录号：2-s2.0-84923269760);WOS:【SCI-EXPANDED(收录号:WOS:000349999200094)】；

基金：We are pleased to acknowledge the financial support from Scientific Research Fund of Xinxiang Medical University (no. 2013QN130).

语种：英文

摘要：A series of novel para-naphthoquinone embodied 4-aza-podophyllotoxin hybrids, designed via a molecular hybridization approach, were synthesized in very good yields using one-pot condensation of 3,4-methylenedioxyaniline, aldehydes and 2-hydroxy-1,4-naphthoquinone in the presence of L-proline. All the synthetic derivatives were fully characterized by spectral data and evaluated for their antitumor activity on human hepatoma cells (HepG2) and the Henrietta Lacks strain of cancer cells (Hela). Among the 18 new compounds screened, 12-(3,4,5-trimethoxyphenyl)-5,10-dihydro-benzo[i][1,3] dioxolo[4,5-b]acridine- 6,11-dione (4o) has pronounced activity. The results demonstrated the potential importance of molecular hybridization in the development of 4o as a potential antitumor agent.