文献类型：期刊文献

英文题名：A SIMPLE EVOLUTIONARY MODEL FOR CANCER CELL POPULATION AND ITS IMPLICATIONS ON CANCER THERAPY

作者：Yao, Peng[1,2];Wen, Shutang[1,2];Li, Baoshun[2];Li, Yuxiao[2]

第一作者：Yao, Peng;姚鹏

通讯作者：Yao, P[1]

机构：[1]Xinxiang Univ, Sch Chem & Chem Engn, Xinxiang 453003, Peoples R China;[2]Zhengzhou Univ, Sch Phys & Engn, Zhengzhou 450052, Peoples R China

第一机构：新乡学院化学化工学院

通讯机构：[1]corresponding author), Xinxiang Univ, Sch Chem & Chem Engn, Xinxiang 453003, Peoples R China.|[110713]新乡学院化学化工学院;[11071]新乡学院;

年份：2009

卷号：23

期号：25

起止页码：2999-3011

外文期刊名：MODERN PHYSICS LETTERS B

收录：;Scopus(收录号：2-s2.0-70349911611);WOS:【SCI-EXPANDED(收录号:WOS:000270693800007)】；

语种：英文

外文关键词：Quasispecies; games theory; differentiation arrest; genotype-phenotype link

摘要：We established a simple evolutionary model based on the cancer stem cell hypothesis. By taking cellular interactions into consideration, we introduced the evolutionary games theory into the quasispecies model. The fitness values are determined by both genotypes and cellular interactions. In the evolutionary model, a cancer cell population can evolve in different patterns. For single peak intrinsic fitness landscape, the evolution pattern can transit with increasing differentiation probability from malignant cells to benign cells in four different modes. For a large enough value of differentiation probability, the evolution is always the case that the malignant cells extinct ultimately, which might give some implications on cancer therapy.