文献类型：期刊文献

英文题名：Asymmetric Synthesis of Tetrahydroisoquinoline Derivatives through 1,3-Dipolar Cycloaddition of C,N-Cyclic Azomethine Imines with Allyl Alkyl Ketones

作者：Feng, Guipeng[1,2];Ma, Guoyang[2];Chen, Wenyan[2];Xu, Shaohong[2];Wang, Kaikai[2];Wang, Shaoyan[1]

第一作者：Feng, Guipeng

通讯作者：Wang, SY[1];Wang, KK[2]

机构：[1]Univ Sci & Technol Liaoning, Sch Chem Engn, Anshan 114051, Peoples R China;[2]Xinxiang Univ, Sch Pharm, Xinxiang 453000, Henan, Peoples R China

第一机构：Univ Sci & Technol Liaoning, Sch Chem Engn, Anshan 114051, Peoples R China

通讯机构：[1]corresponding author), Univ Sci & Technol Liaoning, Sch Chem Engn, Anshan 114051, Peoples R China;[2]corresponding author), Xinxiang Univ, Sch Pharm, Xinxiang 453000, Henan, Peoples R China.|[11071]新乡学院;

年份：2021

卷号：26

期号：10

外文期刊名：MOLECULES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000655053800001)】；

基金：This research was funded by the NSFC (21801214) and Funding of College Students Innovation and Entrepreneurship Training Program of Henan province (S202011071009).

语种：英文

外文关键词：1; 3-dipolar cycloaddition; asymmetric; azomethine imines

摘要：A [3 + 2] 1,3-Dipolar cycloaddition of C,N-cyclic azomethine imines with allyl alkyl ketones has been achieved. The reaction proceeds under mild conditions and tolerates a wide range of functional groups. An array of tetrahydroisoquinoline derivatives is generally constructed with good diastereoselectivities and enantioselectivities (up to >25:1 dr, >95% ee). Moreover, the absolute configuration of the product was previously determined by using the quantum electronic circular dichroism calculation and ECD spectrum method.