文献类型：期刊文献

中文题名：6-异硫氰基-9-苄基嘌呤的绿色合成

英文题名：Green synthesis of 6-isothiocyanato-9-benzyl purine

作者：刘清玲[1];王凯凯[1];吴珊[1]

第一作者：刘清玲

机构：[1]新乡学院化学化工学院

第一机构：新乡学院化学化工学院

年份：2018

卷号：46

期号：5

起止页码：68-71

中文期刊名：河南师范大学学报：自然科学版

收录：CSTPCD;;北大核心:【北大核心2017】；

基金：新乡市第一批科技创新发展专项计划(CXGG16032)

语种：中文

中文关键词：嘌呤;异硫氰酸酯;相转移催化剂

外文关键词：purine;isothiocyanate;phase transfer catalyst

摘要：以6-氯嘌呤为原料,9-位经苄基保护后,与硫氰酸银合成6-异硫氰基-9-苄基嘌呤化合物,并对其合成条件进行了优化.以甲苯/水(体积比为2∶1)作为溶剂,在110℃下反应24h,相转移催化剂SDBS(十二烷基苯磺酸钠)为1mol的条件下,6-异硫氰基-9-苄基嘌呤的产率达到最高(92%收率).目标化合物的结构经~1 H NMR(核磁共振氢谱)、^(13) C NMR(核磁共振碳谱)和HRMS(高分辨质谱)表征,证明合成了目标产物.
The 6-isothiocyanato-9-benzyl-purine was obtained from 6-chloro-9-benzyl purine and silver thiocyanate.The synthetic conditions of 6-isothiocyanato-9-benzyl purine were optimized.6-isothiocyanato-9-benzyl purine had a high yield（92%）when the reaction was carried out in the presence of toluene and H_2 O component solvent which the volume ratio was 2∶1 at 110 ℃for 24 hcatalyzed by 1 mol phase transfer catalyst of sodium dodecyl benzene sulfonate（SDBS）.The structure of the resulting compounds was characterized by ~1 H NMR,^（13） C NMR and HRMS.The results showed that the structure of the target products were consistent with that of the designed compounds.