文献类型：期刊文献

英文题名：Improved Synthesis of Cytidine Diphosphate Choline (CDP-Choline) Via Selective Phosphorylation

作者：Xia, Ran[1];Sun, Li-Ping[2];Chen, Lei-Shan[1]

第一作者：夏然

通讯作者：Xia, R[1]

机构：[1]Xinxiang Univ, Coll Chem & Chem Engn, Xinxiang 453003, Henan, Peoples R China;[2]Xinxiang Univ, Sch Life Sci & Technol, Xinxiang 453003, Henan, Peoples R China

第一机构：新乡学院化学化工学院

通讯机构：[1]corresponding author), Xinxiang Univ, Coll Chem & Chem Engn, Xinxiang 453003, Henan, Peoples R China.|[110713]新乡学院化学化工学院;[11071]新乡学院;

年份：2016

卷号：40

期号：6

起止页码：358-360

外文期刊名：JOURNAL OF CHEMICAL RESEARCH

收录：;Scopus(收录号：2-s2.0-84975801946);WOS:【SCI-EXPANDED(收录号:WOS:000740299500001)，CCR-EXPANDED(收录号:WOS:000378216200010)】；

基金：We are grateful to the Key Scientific Research Projects in the Universities of Henan Province (16A150042) and Science and Technology Innovation Fund of Xinxiang University (15ZP06) for funding.

语种：英文

外文关键词：cytidine diphosphate choline; phosphorylation; scalable synthesis; choline phosphate chloride

摘要：An improved, three-step synthesis of cytidine diphosphate choline (CDP-choline) from cytidine was achieved in 68% overall yield. Selective phosphorylation of cytidine was accomplished by the use of morpholinophosphodichloridate to give cytidine-5 '-phosphomorpholide, which was condensed with choline phosphate chloride in the presence of a catalytic amount of H2SO4 to give CDP-choline. The intermediates and products could be efficiently purified by recrystallisation, thus avoiding the use of chromatography at all stages. The reaction could be scaled up to 200 g in 64% overall yield, making this route attractive for industrial application.