文献类型：期刊文献

英文题名：Perspectives on novel vaccine development

作者：Wang, Y. B.[1];Wang, L. P.[2];Li, P.[2]

第一作者：Wang, Y. B.

通讯作者：Li, P[1]

机构：[1]Xinxiang Med Univ, Sch Publ Hlth, 601 Jinsui Rd, Xinxiang 453003, Henan, Peoples R China;[2]Xinxiang Univ, Sch Life Sci & Technol, Xinxiang 453003, Peoples R China

第一机构：Xinxiang Med Univ, Sch Publ Hlth, 601 Jinsui Rd, Xinxiang 453003, Henan, Peoples R China

通讯机构：[1]corresponding author), Xinxiang Univ, Sch Life Sci & Technol, Xinxiang 453003, Peoples R China.|[1107115]新乡学院生命科学技术学院;[11071]新乡学院;

年份：2018

卷号：21

期号：3

起止页码：643-649

外文期刊名：POLISH JOURNAL OF VETERINARY SCIENCES

收录：;Scopus(收录号：2-s2.0-85057072175);WOS:【SCI-EXPANDED(收录号:WOS:000450720700030)】；

基金：This work was supported by grants from Henan Provincial Science Initiative Program (No. 122102110142) and the Research Plan for Basic Science from the Education Bureau of Henan Province, China (No. 13A230838).

语种：英文

外文关键词：vaccination; vaccinology; novel vaccine development; perspectives

摘要：Vaccination is a common routine for prevention and control of human and animal diseases by inducing antibody responses and cell-mediated immunity in the body. Through vaccinations, smallpox and some other diseases have been eradicated in the past few years. The use of a pathogen itself or a subunit domain of a protein antigen as immunogens lays the basis for traditional vaccine development. But there are more and more newly emerged pathogens which have experienced antigenic drift or shift under antibody selective pressures, rendering vaccine-induced immunity ineffective. In addition, vaccine development has been hampered due to problems including difficulties in isolation and culture of certain pathogens and the antibody-dependent enhancement of viral infection (ADE). How to induce strong antibody responses, especially neutralizing antibody responses, and robust cell-mediated immune responses is tricky. Here we review the progress in vaccine development from traditional vaccine design to reverse vaccinology and structural vaccinology and present with some helpful perspectives on developing novel vaccines.