文献类型：期刊文献

英文题名：Nano γ-Fe2O3-supported fluoroboric acid: A novel magnetically recyclable catalyst for the synthesis of 12-substituted-benzo[h][1,3]dioxolo[4,5-b]-acridine-10,11-diones as potent antitumor agents

作者：Yang, Xiaojuan[1]; Zhang, Chong[2]; Wu, Liqiang[2]

第一作者：杨晓娟

通讯作者：Wu, Liqiang

机构：[1] College of Chemistry and Chemical Engineering, Xinxiang University, Xinxiang Henan, 453003, China; [2] School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, China

第一机构：新乡学院化学化工学院

年份：2015

卷号：5

期号：32

起止页码：25115-25124

外文期刊名：RSC Advances

收录：EI(收录号：20151200655012);Scopus(收录号：2-s2.0-84924862419)

语种：英文

外文关键词：Catalysts - Hematite

摘要：Nano γ-Fe2O3-supported fluoroboric acid was synthesized as a novel magnetic catalyst and characterized. The nanoparticle reagent was obtained with good loading levels and has been successfully used for the efficient and selective synthesis of 12-substituted-benzo[h][1,3]dioxolo[4,5-b]acridine-10,11-diones. The catalyst is quantitatively recovered with an external magnet and can be reused for six cycles with almost consistent activity. In addition, all the synthetic derivatives were fully characterized using spectral data and evaluated for their antitumor activity on human hepatoma cells (HepG2) and Henrietta Lacks strain of cancer cells (HeLa). Among the 19 new compounds screened, 12-(2-fluorophenyl)-benzo[h][1,3]dioxolo[4,5-b]acridine-10,11-dione (4d) has pronounced activity. This journal is ? The Royal Society of Chemistry 2015.